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Meeting

Proceedings
Defence against the Effects of Chemical Hazards: Toxicology, Diagnosis and Medical Countermeasures

RTO-MP-HFM-149

On 8-10 October 2007 NATO representatives from 29 nations met in Edinbourgh, Scotland to attend a symposium on Defense Against the Effects of Chemical Hazards: Toxicology, Diagnosis, and Medical Countermeasures arranged by NATO/RTO/HFM. The Symposium was intended to review state-of-the-art prophylactic, diagnostic, and therapeutic countermeasures, the increasing threat of Toxic Industrial Chemicals (TICs) and Toxic Industrial Materials (TIMs), and discuss future challenges in medical chemical defense. For purposes of summarizing the subject matter the 31 Papers, 11 Posters, and 2 Keynote addresses can be grouped into seven subject areas: NATO/National Policies, Programs and Response to WMD Use; mustard and nerve agent toxicology; diagnostics of OP exposure; toxins; OP medical treatments; operational toxicology; and future of medical countermeasures. The Symposium also addressed how these future medical countermeasures would be enhanced by state-of-the-art medical technologies.

Published10/15/2007
STOAuthorExternal
STOPublicationTypeMeeting Proceedings RDP
Publication_ReferenceRTO-MP-HFM-149
DOI10.14339/RTO-MP-HFM-149
ISBNISBN 978-92-837-0086-9
STOPublisherRTO
AccessOpen Access
STOKeywordsbiological agents; biomarkers; chemical warfare agents; cholinesterase inhibitors; drug therapy; guidelines; hazards; medical countermeasures; medical research; medical services; military chemical agents; models; mustard agents; mustard gas; nerve agents; operational toxicology; procedures; ricin; therapy; toxicity; toxicology; toxins and antitoxins; wmd (weapons of mass destruction)

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MP-HFM-149-03.pdf
  
An Animal Model to Study Health Effects During Long-Term Low Dose Exposure to Toxic Agents10/15/2007Open Access
MP-HFM-149-23.pdf
  
Arsenic Trioxide: Estimation of Health Risks on the Basis of Toxicokinetics Indices10/15/2007Open Access
MP-HFM-149-22.pdf
  
Assessment of Respiratory and Renal Functions Among Gas Metal Arc Welders and Their Relations with Chromium Exposure10/15/2007Open Access
MP-HFM-149-24.pdf
  
Biomonitoring of Exposure to Permethrin Based on Adducts to Proteins10/15/2007Open Access
MP-HFM-149-18.pdf
  
Central Cholinesterase Reactivation by Oximes Improves Survival and Terminates Seizures Following Nerve Agent Intoxication10/15/2007Open Access
MP-HFM-149-11.pdf
  
Comparison of Deposition Patterns for Small and Large Particle Aerosolized Toxins and Resulting Disease in Guinea Pigs and African Green Monkeys10/15/2007Open Access
MP-HFM-149-15.pdf
  
Comparison of Pre-Treatment Regimens Against Soman: In Vivo and in Vitro Analysis of Treatment Tolerability and Efficacy10/15/2007Open Access
$MP-HFM-149-COVER.pdf
  
Cover Pages10/15/2007Open Access
MP-HFM-149-14.pdf
  
Critical Role of the Sodium Hydrogen Exchanger in Maitotoxin-Induced Neuronal Cell Death in Cultured Rat Cortical Neurons10/15/2007Open Access
MP-HFM-149-17.pdf
  
Development of New Reactivators of Tabun Inhibited Acetylcholinesterase and the Evaluation of Their Efficacy by in Vitro and in Vivo Methods10/15/2007Open Access
MP-HFM-149-08.pdf
  
Distortion Product Otoacoustic Emissions as Potential Non-Invasive Predictors and Biomarkers of Soman-Induced Central Neurotoxicity10/15/2007Open Access
MP-HFM-149-25.pdf
  
Environmental Hazard in Vitro Biomarker Discovery Tools10/15/2007Open Access
MP-HFM-149-07.pdf
  
Estimating Miotic, Severe and Lethal Toxic Effects in Gottingen Minipigs Following Inhalation, Intravenous and Subcutaneous Exposures to VX10/15/2007Open Access
$MP-HFM-149-ES.pdf
  
Executive Summary and Synthèse10/15/2007Open Access
MP-HFM-149-05.pdf
  
Gene Expression Profiles of Vesicant-Induced Skin Injury10/15/2007Open Access
MP-HFM-149-04.pdf
  
Gene Expression Responses to Sulphur Mustard10/15/2007Open Access
MP-HFM-149-06.pdf
  
Inhalation Toxicology of Sulphur Mustard: Dose Ranging Study in a Porcine Model10/15/2007Open Access
MP-HFM-149-28.pdf
  
Intracellular Acidification: The Initiating Event in Sulphur Mustard Induced Cytotoxicity10/15/2007Open Access
MP-HFM-149-27.pdf
  
Low-Level Toxicology and the Human Toxicity Estimates10/15/2007Open Access
$MP-HFM-149-KN2.pdf
  
Medical Countermeasures to Weapons of Mass Destruction: The NATO Advantage ; ; Medical countermeasures to Weapons of Mass Destruction: The NATO Advantage10/15/2007Open Access
MP-HFM-149-29.pdf
  
Novel Mechanism to Explain Ketamine Efficacy Against Nerve Agent-Induced Seizures10/15/2007Open Access
MP-HFM-149-19.pdf
  
Pharmacological Screening of Anticonvulsants against Nerve Agents: Limitations by Conventional Approach10/15/2007Open Access
$MP-HFM-149-PC.pdf
  
Programme Committee10/15/2007Open Access
MP-HFM-149-16.pdf
  
Prophylaxis Against Nerve Agent Toxicity: Physiological, Behavioral, and Neuroprotection of Current and Novel Treatments10/15/2007Open Access
MP-HFM-149-10.pdf
  
Red Blood Cell Acetylcholinesterase and Cholinesterase Status: Important Tools for the Physician in a Nerve Agent Scenario;10/15/2007Open Access
MP-HFM-149-13.pdf
  
Retrospective Identification of Ricin in Animal Tissues Following Administration by Pulmonary and Oral Routes10/15/2007Open Access
MP-HFM-149-26.pdf
  
Risk Management of Exposure to Chemicals under Operational Conditions10/15/2007Open Access
MP-HFM-149-02.pdf
  
Soman-Induced Neuro-Inflammatory Reaction in Mouse Brain. Some Effects of a Combination of Atropine and Ketamine10/15/2007Open Access
MP-HFM-149-21.pdf
  
Some Mechanisms of Toxic Action of Irritants10/15/2007Open Access
MP-HFM-149-31.pdf
  
Stoichiometric and Catalytic Scavengers as Protection against Nerve Agent Toxicity10/15/2007Open Access
MP-HFM-149-30.pdf
  
Strategies for the Development of Effective Broad-Spectrum Oximes10/15/2007Open Access
MP-HFM-149-20.pdf
  
Studies to Evaluate Novel Neuroprotectants in a Rat Model of Soman Exposure Reveal Episodes of Status Epilepticus and Spontaneous Recurrent Seizures Even with Initial Oxime, Atropine and Diazepam Therapeutics10/15/2007Open Access
$MP-HFM-149-T.pdf
  
Technical Evaluation Report10/15/2007Open Access
MP-HFM-149-01.pdf
  
Temporal Expression of Neuroinflammatory Markers and Brain Injury Following Acute Soman Poisoning10/15/2007Open Access
MP-HFM-149-12.pdf
  
The Production and Evaluation of Ricin Antitoxins10/15/2007Open Access
MP-HFM-149-09.pdf
  
Verification of Exposure to Organophosphates: Detection of an Unknown Cholinesterase Inhibitor;10/15/2007Open Access

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